Episodes: 12 | Released: 2010 | Certificate: 15 | Genre: Comedy | Director: Paul Feig
Actors: Edie Falco
, Eve Best
, Peter Facinelli
, Merritt Wever
, Paul Schulze
, Anna Deavere Smith
, Dominic Fumusa
After the confrontation with Eddie at the end of season one, it's a few months later and Jackie is on the beach with her family. She's cut ties with Eddie and is determined to dive back in and spend more time with her family.
After a morning dealing with Grace's escalating anxiety, Jackie helps a struggling family speed along a test to diagnose a little boy's cystic fibrosis. But cutting through the red tapes leads to sending the patient home with wrong information.
During an after school playdate, Ginny Flynn and Kaitlin annoy Jackie with their presence and Kaitlyn catches Jackie snorting a line of Adderal. Kevin tells Jackie he doesn't like O'Hara's offer of money for the girls, afraid of being indebted to her. Coop checks up on Eddie at his new job (Excelsior Drugs) and brags about being listed as one of the Top 25 Doctors in New York Magazine. Jackie's last minute overtime leaves Kevin in the lurch, with both working and no one to pick up the kids. She comes home to find the girls playing "Candyland" with Kevin and Eddie.
Jackie confronts Eddie about his stalking her and wants him to stay away from her family. Coop and Jackie are at odds about how to treat a cancer patient's nausea from chemo. Jackie provides him relief with medical marijuana even though it's illegal in New York. Eddie takes Kevin to a baseball game on what was supposed to be Kevin and Jackie's date night and throws it in Jackie's face. Zoey intubates a patient against the rules and reveals to Jackie that she thinks she's pregnant. O'Hara seduces Sam the nurse.
Jackie overreacts to Kevin's movie date with Ginny Flynn and the girls. Akalitus stations a security guard at the Pill-O-Matix making it harder for Jackie. Akalitus asks Coop to be the Face of All Saints - a city-wide ad campaign using his image to bring in more insured patients. O'Hara confesses to Jackie that she has had an on-again, off-again relationship with foreign correspondent Sarah Khouri. Sam ends things with O'Hara before she can. Zoey, still anxious about her possible pregnancy, throws herself into work. After relentless texts from Eddie, Jackie calls him for the first time in months and they meet up and go to a movie together.
Jackie sleeps with Eddie at his apartment and tells him to stop seeing Kevin. Posters with Coop's face are plastered all over the city much to the disgust of Jackie and O'Hara. Jackie treats a female Iraq war vet with PTSD who tried to kill herself. O'Hara's ex, Sarah Khouri, comes to town and they're back on. With Eddie and the Pill-o-matix becoming less reliable sources, Jackie finds ways to get pills from other places (a pharmaceutical rep). Eddie ignores Jackie's request and invites Kevin to a ping pong club and Jackie shows up. Jackie allows Fiona to have a fake cast on her arm for her birthday.
Post-birthday party, Fi busts her lip open on her cast and O'Hara and Jackie stitch her up in the Peyton kitchen.
Jackie deals with Fiona's teacher's concerns and suspicions about her busted lip and cast. Coop sets his friend Georgia up with Eddie. O'Hara, having once again ended things with Sarah, takes comfort with spending time with Jackie and her family in Queens.
Jackie tells Kevin she wants to send Fiona to Immaculate with Grace. Kevin makes Jackie promise not to accept money from O'Hara. Jackie rents a P.O. Box in order to safely receive her secret credit card bill that she's now using to pay for prescriptions. Jackie lies to O'Hara and says Kevin agreed to accept her offer of money for the girls. O'Hara tells Jackie she needs to get an MRI of her back. During an unusually busy day at the hospital, Akalitus jumps in to assist the nurses and after being back in the trenches, decides to get rid of the broken down Pill-O-Matix and bring Eddie back. Coop's Tourrettes kicks in, this time he grabs Zoey's breasts in front of Lenny who punches him, breaking his nose. Jackie discovers that Grace's anxiety has led to tricotillomania (pulling out her hair).
Jackie shows O’Hara a fake MRI of a messed up back so that she can get a prescription of Oxy. O’Hara confronts Orthopedics and finds out that Jackie faked her MRI. Akalitus hires Eddie back as the pharmacist. Akalitus and Jackie advise the wife of a patient to divorce him so that they can avoid going bankrupt and he can qualify for Medicaid. Coop is distraught over the end of the Face of All Saints campaign and offers to pay for a new round of ad space. Sam invites Coop to hang with his friends and his girlfriends after work. On Jackie’s way home, she helps a businessman having a seizure and discovers baggies of r/x pills in his jacket—he’s a white collar drug dealer. Jackie steals three Ziplocs of pills from him while they wait for EMS.
After avoiding Eddie, O'Hara and the drug dealer who has come looking for his stolen pills, Jackie takes off early for a family vacation upstate. Kevin and the girls are excited but every activity they've planned is a disaster.
Having returned from a disastrous family vacation, Jackie returns to work for a day of reckoning. The mounting pressures and conflicts in her personal and professional life reach a boiling point. And unexpected alliances lead to revelations that even Jackie can't avoid. Between O'Hara, Eddie, Kevin and the drug dealer, the wagons are circling around Jackie Peyton.
